Structure of PDB 6rxr Chain D

Receptor sequence

>6rxrD (length=226) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPEAPLRPHVVWFGEMPLGMD
EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN
EFAEKYYGPASQVVPEFVEKLLKGLK

3D structure

PDB

6rxr Evolved, Selective Erasers of Distinct Lysine Acylations.

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.286: protein acetyllysine N-acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	V188 F190 G191 E192 M193 Y201 H218 V219 Y220 P221	V140 F142 G143 E144 M145 Y153 H170 V171 Y172 P173
BS02	KMQ	D	G48 A49 G50 E54 F60 W67 Q129 H147 V188 F190 G214 T215 S216 N240 L241 P257 A258	G9 A10 G11 E15 F21 W28 Q90 H108 V140 F142 G166 T167 S168 N192 L193 P209 A210

Gene Ontology

	Molecular Function
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:6rxr, PDBe:6rxr, PDBj:6rxr
PDBsum	6rxr
PubMed	32187803
UniProt	P75960\|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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