Structure of PDB 6rxq Chain D

Receptor sequence
>6rxqD (length=226) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPEAPLRPHVVWFGEMPLGMD
EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN
EFAEKYYGPASQVVPEFVEKLLKGLK
3D structure
PDB6rxq Evolved, Selective Erasers of Distinct Lysine Acylations.
ChainD
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D V188 F190 G191 E192 M193 Y201 H218 V219 Y220 P221 V140 F142 G143 E144 M145 Y153 H170 V171 Y172 P173
BS02 KMQ D G48 A49 G50 E54 F60 W67 Q129 H147 V188 F190 G214 T215 S216 N240 L241 A258 G9 A10 G11 E15 F21 W28 Q90 H108 V140 F142 G166 T167 S168 N192 L193 A210
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxq, PDBe:6rxq, PDBj:6rxq
PDBsum6rxq
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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