Structure of PDB 6ru8 Chain D

Receptor sequence
>6ru8D (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI
ESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFS
LKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFG
LAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGY
VLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATY
LNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB6ru8 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
ChainD
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D S19 D128 K130 L152 L173 T174 G175 T176 R178 Q214 G215 K224 Y225 S18 D127 K129 L151 L172 T173 G174 T175 R177 Q213 G214 K223 Y224
BS02 ADP D G18 I23 A36 K38 E52 Y56 M82 L85 L135 I148 D149 G17 I22 A35 K37 E51 Y55 M81 L84 L134 I147 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ru8, PDBe:6ru8, PDBj:6ru8
PDBsum6ru8
PubMed32719556
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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