Structure of PDB 6rmm Chain D

Receptor sequence
>6rmmD (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
LFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLGC
EVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVI
SFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERG
GSKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIENS
3D structure
PDB6rmm Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
ChainD
Resolution3.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D E677 Y678 F679 V680 R681 M689 K704 E126 Y127 F128 V129 R130 M138 K153
External links
PDB RCSB:6rmm, PDBe:6rmm, PDBj:6rmm
PDBsum6rmm
PubMed31135337
UniProtQ92547|TOPB1_HUMAN DNA topoisomerase 2-binding protein 1 (Gene Name=TOPBP1)

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