Structure of PDB 6r5f Chain D

Receptor sequence
>6r5fD (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
KMKSSDFLVSLAFHRTQGLMIMKTVCIEHNEALLEEAKMMNRLRHSRVVK
LLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMA
YLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNGTLYYMA
PEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIAEQQLIMAIKSG
NRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLE
3D structure
PDB6r5f Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
ChainD
Resolution3.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D111 K113 E115 N116 D129 T145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JSW D K45 M67 L70 V76 L78 M92 I154 A155 D156 L157 F162 K23 M40 L43 V49 L51 M65 I127 A128 D129 L130 F135
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6r5f, PDBe:6r5f, PDBj:6r5f
PDBsum6r5f
PubMed31013427
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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