Structure of PDB 6qzv Chain D

Receptor sequence
>6qzvD (length=812) Species: 9606 (Homo sapiens) [Search protein sequence]
PAARFQVQKHSWDGLRSIIHGSRKAPHDFQFVQKTDEGPHSHRLYYLGMP
RENSLLYSEIPKLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFG
ITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPR
MDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQVLDDPKSAGVA
TFVIQEEFDRFTGYWWCPTASWEGLKTLRILYEEVDESEVEVIHVPSPAL
EERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSL
FPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQ
RLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEDELCFLRANEC
KTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVL
ARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFS
HSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMME
AADYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQL
VNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVE
IEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAI
AGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLL
ILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHY
EVTLLHFLQEYL
3D structure
PDB6qzv Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
ChainD
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y644 S730 Y731 D808 H840
Catalytic site (residue number reindexed from 1) Y593 S679 Y680 D757 H789
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D R133 E248 E249 H500 Q648 S730 Y762 Y766 N810 H840 R95 E206 E207 H453 Q597 S679 Y711 Y715 N759 H789
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0043069 negative regulation of programmed cell death
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0031252 cell leading edge

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qzv, PDBe:6qzv, PDBj:6qzv
PDBsum6qzv
PubMed
UniProtQ86TI2|DPP9_HUMAN Dipeptidyl peptidase 9 (Gene Name=DPP9)

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