Structure of PDB 6qv0 Chain D

Receptor sequence

>6qv0D (length=574) Species: 243274 (Thermotoga maritima MSB8)

LKNPTATLRRLLGYLRPHTFTLIMVFVFVTVSSILGVLSPYLIGKTIAVV
FVPRRFDLLPRYMLILGTIYALTSLLFWLQGKIMLTLSQDVVFRLRKELF
EKLQRVPVGFFDRTPHGDIISRVINDVDNINNVLGNSIIQFFSGIVTLAG
AVIMMFRVNVILSLVTLSIVPLTVLITQIVSSQTRKYFYENQRVLGQLNG
IIEEDISGLTVIKLFTREEKEMEKFDRVNESLRKVGTKAQIFSGVLPPLM
NMVNNLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLNELSNQF
NMIQMALASAERIFEILDLEEEKDDPDAVELREVRGEIEFKNVWFSYDKK
KPVLKDITFHIKPGQKVALVGPTGSGKTTIVNLLMRFYDVDRGQILVDGI
DIRKIKRSSLRSSIGIVLQDTILFSTTVKENLKYGNPGATDEEIKEAAKL
THSDHFIKHLPEGYETVLTDNGEDLSQGQRQLLAITRAFLANPKILILDA
ATSNVDTKTEKSIQAAMWKLMEGKTSIIIAHRLNTIKNADLIIVLRDGEI
VEMGKHDELIQKRGFYYELFTSQY

3D structure

• PDB: 6qv0 The extracellular gate shapes the energy profile of an ABC exporter.
• Chain: D
• Resolution: 3.12 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	D	D491 S493 G495 Q496	D474 S476 G478 Q479
BS02	ATP	D	Y364 V370 T390 G391 G393 K394 T395 T396 Q436 H548	Y347 V353 T373 G374 G376 K377 T378 T379 Q419 H531
BS03	MG	D	T395 Q436	T378 Q419

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6qv0, PDBe:6qv0, PDBj:6qv0
• PDBsum: 6qv0
• PubMed: 31113958
• UniProt: Q9WYC4|Y288_THEMA Uncharacterized ABC transporter ATP-binding protein TM_0288 (Gene Name=TM_0288)