Structure of PDB 6qtk Chain D

Receptor sequence
>6qtkD (length=192) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
PGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNV
EKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGA
HIRTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNP
EHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYA
3D structure
PDB6qtk Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
ChainD
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D K460 L462 N463 K466 R471 H515 V626 R629 K46 L48 N49 K52 R57 H101 V178 R181
BS02 dna D E435 G436 D437 R458 G459 K460 D512 E21 G22 D23 R44 G45 K46 D98
BS03 MN D E435 D508 E21 D94
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6qtk, PDBe:6qtk, PDBj:6qtk
PDBsum6qtk
PubMed30757898
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB)

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