Structure of PDB 6qic Chain D

Receptor sequence

>6qicD (length=629) Species: 759272 (Thermochaetoides thermophila DSM 1495)

MSIKEQRESLPVFQFRDQIIQAVKDNQILIVVGETGSGKTTQVTQYLAEA
GFTKYGMIGCTQPRRVAAVSVAKRVAEEVGCQLGQEVGYTIRFEDVTSPA
TKIKYMTDGMLQREILMDPDLKRYSVIMLDEAHERTIATDVLFALLKKTV
KRRPDLKVIVTSATLDAEKFSEYFNSCPIFTIPGRTFPVEILYSREPEPD
YLEAALTTVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKALGPSVP
ELIILPIYSALPSEMQSRIFEPAPPGSRKVVIATNIAETAITIDYIYYVV
DPGFVKQNAYDPKLGMDSLVVTPISQAQANQRAGRAGRTGPGKCFRLYTE
AAYQSEMLPTTIPDIQRQNLANTILLLKAMGINDLLRFDFMDPPPVNTML
TALEELYALGALDDEGLLTRLGRKMADFPMEPSLSKVLIASVDKGCSDEM
VTIVSMLNLQQIFYRPKDKQQQADQKKAKFHDPTGDHLTLLNVYNAWKNS
GYSNAWCFENYIQARAMRRARDVRQQIVKIMERHRHPIISCGRDTDKIRQ
ALCAGFFRNTARKDPGYKTLTEGTPVYLHPSSALFGKQAEWVLYHELVLT
TKEYMHFTTAIEPKWLVEAAPTFFKLAPT

3D structure

• PDB: 6qic Structural basis for RNA translocation by DEAH-box ATPases.
• Chain: D
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	R611 R612 R639 T654 G656 M657 R660 G774 Q775 E776 S806 T831 N832 K853 L866 P976 R1012 Q1073 I1077 R1080 H1128 P1129 F1134 T1149 K1151 Y1153 H1155	R64 R65 R92 T107 G109 M110 R113 G227 Q228 E229 S259 T284 N285 K306 L319 P429 R465 Q526 I530 R533 H579 P580 F585 T600 K602 Y604 H606

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:6qic, PDBe:6qic, PDBj:6qic
• PDBsum: 6qic
• PubMed: 30828714
• UniProt: G0S700