Structure of PDB 6qf7 Chain D

Receptor sequence
>6qf7D (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
SCGQRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDR
PAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRL
QEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYAS
FLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPL
VCEDRRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
3D structure
PDB6qf7 Crystal structures of the recombinant beta-factor XIIa protease with bound Thr-Arg and Pro-Arg substrate mimetics.
ChainD
Resolution4.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H393 D442 Q541 G542 D543 S544
Catalytic site (residue number reindexed from 1) H45 D94 Q193 G194 D195 S196
Enzyme Commision number 3.4.21.38: coagulation factor XIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 D H393 Y439 D538 A539 S544 S563 W564 G565 H45 Y91 D190 A191 S196 S214 W215 G216
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6qf7, PDBe:6qf7, PDBj:6qf7
PDBsum6qf7
PubMed31205020
UniProtP00748|FA12_HUMAN Coagulation factor XII (Gene Name=F12)

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