Structure of PDB 6qat Chain D

Receptor sequence
>6qatD (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
MEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQ
ILLGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAK
GTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYAVSGIRIKI
ADFGFARYLPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANS
PQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSH
PF
3D structure
PDB6qat Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
ChainD
Resolution2.77 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D131 K133 Q135 N136 D158
Catalytic site (residue number reindexed from 1) D131 K133 Q135 N136 D152
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE7 D V15 A37 E86 Y87 C88 L138 V15 A37 E86 Y87 C88 L138
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010506 regulation of autophagy

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6qat, PDBe:6qat, PDBj:6qat
PDBsum6qat
PubMed30782972
UniProtQ8IYT8|ULK2_HUMAN Serine/threonine-protein kinase ULK2 (Gene Name=ULK2)

[Back to BioLiP]