Structure of PDB 6q9q Chain D

Receptor sequence
>6q9qD (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
NQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMV
YCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVT
3D structure
PDB6q9q Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.
ChainD
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HUE D M54 L57 G58 I61 M62 Y67 Q72 V93 L99 M29 L32 G33 I36 M37 Y42 Q47 V68 L74 MOAD: ic50=145nM
BS02 O4B D L32 K36 L7 K11
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6q9q, PDBe:6q9q, PDBj:6q9q
PDBsum6q9q
PubMed31066983
UniProtO15151|MDM4_HUMAN Protein Mdm4 (Gene Name=MDM4)

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