Structure of PDB 6pyy Chain D

Receptor sequence
>6pyyD (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILW
ELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTAL
DFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEE
NELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF
IRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRA
LQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGS
KSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLEH
3D structure
PDB6pyy Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.11: tryptophan 2,3-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H7S D Y42 Y45 Y4 Y7 MOAD: ic50=424uM
BindingDB: IC50=>50000nM
BS02 HEM D F72 H76 Y79 L132 F140 G152 F158 R159 H328 M331 V332 M335 Y350 L351 F34 H38 Y41 L94 F102 G114 F120 R121 H290 M293 V294 M297 Y306 L307
BS03 H7S D F72 H76 A150 S151 F34 H38 A112 S113 MOAD: ic50=424uM
BindingDB: IC50=>50000nM
BS04 H7S D R103 W208 R211 T212 P213 R303 F304 R65 W170 R173 T174 P175 R265 F266 MOAD: ic50=424uM
BindingDB: IC50=>50000nM
Gene Ontology
Molecular Function
GO:0004833 tryptophan 2,3-dioxygenase activity
GO:0005515 protein binding
GO:0016597 amino acid binding
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006568 tryptophan metabolic process
GO:0006569 tryptophan catabolic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0019442 tryptophan catabolic process to acetyl-CoA
GO:0051289 protein homotetramerization
GO:1904842 response to nitroglycerin
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pyy, PDBe:6pyy, PDBj:6pyy
PDBsum6pyy
PubMed31682426
UniProtP48775|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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