Structure of PDB 6ptw Chain D

Receptor sequence
>6ptwD (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
NTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEH
KGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDIC
QKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDW
3D structure
PDB6ptw Multivalent assembly of KRAS with the RAS-binding and cysteine-rich domains of CRAF on the membrane.
ChainD
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C452 H473 C97 H118
BS02 ZN D H439 C465 C468 C484 H84 C110 C113 C129
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:6ptw, PDBe:6ptw, PDBj:6ptw
PDBsum6ptw
PubMed32414921
UniProtP04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Gene Name=RAF1)

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