Structure of PDB 6pet Chain D

Receptor sequence
>6petD (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLDA
3D structure
PDB6pet Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
ChainD
Resolution2.203 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G9J D L346 T347 A350 E353 F404 I424 H524 L525 L41 T42 A45 E48 F99 I119 H216 L217
External links
PDB RCSB:6pet, PDBe:6pet, PDBj:6pet
PDBsum6pet
PubMed31311734
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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