Structure of PDB 6pek Chain D

Receptor sequence
>6pekD (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
RNVDSNLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPEL
FTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVG
EGEKLVRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLI
EFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLL
LKNLLCKQGSPLTQKELAQLARMTDGYSGSDLTALAKDAALGPIRELKPE
QVKNMSASEMRNIRLSDFTESLKKIKRSVSPQTLEAYIRWNKD
3D structure
PDB6pek Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
ChainD
Resolution4.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D K414 Y415 V416 H455 K97 Y98 V99 H138
BS02 ADP D D470 R498 D153 R181
BS03 ADP D D343 A345 G385 N386 G387 K388 T389 M390 G546 D26 A28 G68 N69 G70 K71 T72 M73 G229
BS04 BEF D P384 G385 K388 P67 G68 K71
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6pek, PDBe:6pek, PDBj:6pek
PDBsum6pek
PubMed31767681
UniProtQ9UBP0|SPAST_HUMAN Spastin (Gene Name=SPAST)

[Back to BioLiP]