Structure of PDB 6p8x Chain D

Receptor sequence
>6p8xD (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
SLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHK
3D structure
PDB6p8x Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
ChainD
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP D G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147 G13 G15 K16 S17 A18 F28 D30 N116 K117 D119 S145 A146 K147
BS02 O5V D V9 C12 K16 R68 M72 D92 H95 Y96 Q99 V9 C12 K16 R68 M72 D92 H95 Y96 Q99
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6p8x, PDBe:6p8x, PDBj:6p8x
PDBsum6p8x
PubMed31531201
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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