Structure of PDB 6p07 Chain D

Receptor sequence
>6p07D (length=303) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
VVSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSV
RPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTS
KYVGDGEKLVRALFAVARHMQPSIIFIDQVDSLLSERSSSEHEASRRLKT
EFLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQ
TRELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIR
ELNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYG
DIT
3D structure
PDB6p07 An allosteric network in spastin couples multiple activities required for microtubule severing.
ChainD
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D K555 V557 H596 A598 K101 V103 H142 A144
BS02 ATP D R640 R641 R186 R187
BS03 ATP D A486 G526 N527 G528 K529 T530 Q583 N629 L659 A32 G72 N73 G74 K75 T76 Q129 N175 L205
BS04 MG D T530 D582 T76 D128
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6p07, PDBe:6p07, PDBj:6p07
PDBsum6p07
PubMed31285604
UniProtA0A0B4LHJ5

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