Structure of PDB 6oyt Chain D

Receptor sequence
>6oytD (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
MESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERS
QPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSK
WGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLK
ISDFGTSKRLAGTLQYMAPEIIYGKAADIWSLGCTIIEMATGKPPFYEPQ
AAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL
KHH
3D structure
PDB6oyt Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
ChainD
Resolution2.824 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D134 K136 D138 N139 D153 T163
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NJV D L686 G687 V694 A707 K709 M754 E755 Q756 V757 P758 G759 L810 D822 L21 G22 V29 A42 K44 M85 E86 Q87 V88 P89 G90 L141 D153 BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6oyt, PDBe:6oyt, PDBj:6oyt
PDBsum6oyt
PubMed31710475
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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