Structure of PDB 6ovt Chain D

Receptor sequence
>6ovtD (length=560) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
VADIKPRSRDVTDGLEKAAARGMLRAVGMDDEDFAKPQIGVASSWNEITP
CNLSLDRLANAVKEGVFSAGGYPLEFGTISVSDGISMGHEGMHFSLVSRE
VIADSVEVVMQAERLDGSVLLAGCDKSLPGMLMAAARLDLAAVFLYAGSI
LPGRAKLSDGSERDVTIIDAFEAVGACSRGLMSRADVDAIERAICPGEGA
CGGMYTANTMASAAEALGMSLPGSAAPPATDRRRDGFARRSGQAVVELLR
RGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAHEANVALSLQDF
SRIGSGVPHLADVKPFGRHVMSDVDHIGGVPVVMKALLDAGLLHGDCLTV
TGHTMAENLAAITPPDPDGKVLRALANPIHPSGGITILHGSLAPEGAVVK
TAGSDVFEGTARVFDGERAALDALEDGTITVGDAVVIRYEGPKGGPGMRE
MLAITGAIKGAGLGKDVLLLTDGRFSGGTTGLCVGHIAPEAVDGGPIALL
RNGDRIRLDVAGRVLDVLADPAEFASRQQDFSPPPPRYTTGVLSKYVKLV
SSAAVGAVCG
3D structure
PDB6ovt The active site of theMycobacterium tuberculosisbranched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.
ChainD
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.9: dihydroxy-acid dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D D96 D138 K139 D83 D125 K126
BS02 FES D C64 G97 C137 D138 A213 C214 C51 G84 C124 D125 A200 C201
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004160 dihydroxy-acid dehydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ovt, PDBe:6ovt, PDBj:6ovt
PDBsum6ovt
PubMed31315931
UniProtP9WKJ5|ILVD_MYCTU Dihydroxy-acid dehydratase (Gene Name=ilvD)

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