Structure of PDB 6oiu Chain D

Receptor sequence

>6oiuD (length=886) Species: 508771 (Toxoplasma gondii ME49)

EKHRLDYKPTDFLIDFVDLDFDLYDDRTKVTSTLTMHRREQTPPTDLVLD
GEDLELESVELDGNALSMHSTETQKAGDRVYSLDVDGRLVIAADLLPQEA
EKKFKVKTVVYVRPKENLQLMGLYKSGALLVTQCEAEGFRRITYFLDRPD
VMSLFKVRLAADEKACPVLLSNGNMVESGKVEGEKGRHFAVFEDPFQKPC
YLFALVAGDLKSISQSFTTMSGRNVKVSIFSEPEDSSKLTWALESVLKSM
KWDEERFGREYDLDVFNVVCAKDFNMGAMENKGLNIFNAALLLADPSTTT
DAEYQRILNVVGHEYFHQWTGNRVTCRDWFQLTLKEGLTVFRDQLFTADM
CSAAVKRIEDVVFLRSRQFAEDSGPMAHPIRPETYIAMDNFYTATVYDKG
AEVIRMYHTLLGEAGFRKGMDLYFKRHDGKAVTCDDFRAAMADANGRDLG
QFERWYLQAGTPEVTVSEAVFQPDRKKFKLTLKQRTPPTPGQVEKHPFHI
PIKVGLIGKTSKKDILSPPTKVLELTEAEQTFELDAAEDCVLSFLRDFSA
PVKVKHEQTDEDIAFLMAHDSDDFAKWQAAHTLASGLLKHRAEQWREKQG
EDVEFARLPKIYVEAFKQTLLEQGDRSIQAYTLRLPDRDGVAQEMEPIDP
LALKEATESVRREVGQLLKSDLLKVYASLSAESRDQSEVSRRRLRNVILY
FLTGERDKEAAALAMNHFKSAKGMTEKYAALSILCDIEGPERTAALEQFY
RDAKGDPLVLDKWFAVQALSDVRQVTETVKELQKHADFTAKNPNRLRALI
FSFTRNPQFHNKDGAGYALLADSVLAVDRFNPQIAARGAGAFLQWKKYDE
TRQREMLKQLRRIANAPGLSVDTLEIVQKALAGAPE

3D structure

• PDB: 6oiu X-ray crystal structure and specificity of the Toxoplasma gondii ME49 TgAPN2.
• Chain: D
• Resolution: 2.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E802 H835 E836 H839 E858 D911 Y919
• Catalytic site (residue number reindexed from 1): E280 H313 E314 H317 E336 D389 Y397
• Enzyme Commision number: 3.4.11.2: membrane alanyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	D	H835 H839 E858	H313 H317 E336

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:6oiu, PDBe:6oiu, PDBj:6oiu
• PDBsum: 6oiu
• PubMed: 32926129
• UniProt: S8G5K8