Structure of PDB 6ofc Chain D

Receptor sequence
>6ofcD (length=661) Species: 83331 (Mycobacterium tuberculosis CDC1551) [Search protein sequence]
MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVF
PELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRHR
HRIYNTAVVIHRGAVLGVVPKSYLPTYREFYERRQMAPGDGERGTIRIGG
ADVAFGTDLLFAASDLPGFVLHVEIAEDMFVPMPPSAEAALAGATVLANL
SGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLAWDGQTMI
WENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRRHHRELT
ESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAYNIQVSG
LEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSDILAFALP
GFHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYSVGEKVYDVTF
ENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYGVGDQMSHYNV
NAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITEAKVGPFALQD
FSLFQVLRYGFRPSKIAFLAWHAWNDAERGNWPPGFPKSERPSYSLAEIR
HWLQIFVQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAPSDMSARIW
LDQIDREVPKG
3D structure
PDB6ofc Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD+synthetases.
ChainD
Resolution3.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.5.1: NAD(+) synthase (glutamine-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFH D R354 L358 N471 H501 R354 L358 N467 H497
BS02 SFH D G489 S491 F634 K635 G485 S487 F616 K617
BS03 GLN D L215 R218 L215 R218
BS04 SFH D G366 V367 S368 L399 R462 T480 W490 T492 G366 V367 S368 L399 R458 T476 W486 T488
BS05 GLN D F130 F180 S203 R209 F130 F180 S203 R209
Gene Ontology
Molecular Function
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0008795 NAD+ synthase activity
GO:0016874 ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0009435 NAD biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ofc, PDBe:6ofc, PDBj:6ofc
PDBsum6ofc
PubMed31911602
UniProtP9WJJ3|NADE_MYCTU Glutamine-dependent NAD(+) synthetase (Gene Name=nadE)

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