Structure of PDB 6o0n Chain D

Receptor sequence
>6o0nD (length=516) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVR
IDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIV
LSANRPYELLEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRV
LAAATGARTANAGPVHFDIPLRVTPPGRPAGKPWTYTPPVTFDQPLDIDL
SVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQV
IMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTG
APRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQL
VLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAH
ERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGG
GSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKA
DRSSLRQLHAAIKAAL
3D structure
PDB6o0n Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
ChainD
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.9: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DNA D Y95 R97 R277 R303 W304 P305 Y93 R95 R255 R281 W282 P283
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016740 transferase activity
GO:0030145 manganese ion binding
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
GO:0070204 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6o0n, PDBe:6o0n, PDBj:6o0n
PDBsum6o0n
PubMed32029475
UniProtP9WK11|MEND_MYCTU 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (Gene Name=menD)

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