Structure of PDB 6nvl Chain D

Receptor sequence
>6nvlD (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
WELPRDRLVLGKQVVLAEAIGLDKPNRVTKVAVKMLKSTEKDLSDLISEM
EMMKMIGKHKNIINLLGACTGPLYVIVEYASKGNLREYLQARRPPGLEYS
YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED
NVMKIADFGLYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI
FTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQ
RPTFKQLVEDLDRIVALTS
3D structure
PDB6nvl Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.
ChainD
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D623 R627 N628 D641
Catalytic site (residue number reindexed from 1) D139 R143 N144 D157
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XL6 D A512 K514 E531 M535 I545 V561 Y563 A564 S565 L630 A640 F642 A32 K34 E49 M53 I63 V77 Y79 A80 S81 L146 A156 F158
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor receptor activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6nvl, PDBe:6nvl, PDBj:6nvl
PDBsum6nvl
PubMed31413803
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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