Structure of PDB 6nj7 Chain D

Receptor sequence
>6nj7D (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARTLQKVVSHCLE
LGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFH
DDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVHMQ
AAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYST
3D structure
PDB6nj7 Mechanistic Insight on the Mode of Action of Colletoic Acid.
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.146: 11beta-hydroxysteroid dehydrogenase.
1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D G41 S43 G45 I46 R66 T92 M93 N119 I121 V168 S170 Y183 K187 G216 I218 T220 T222 A223 G14 S16 G18 I19 R39 T62 M63 N89 I91 V138 S140 Y153 K157 G186 I188 T190 T192 A193
BS02 7H6 D S170 Y183 S140 Y153 BindingDB: IC50=13nM,Ki=620nM
Gene Ontology
Molecular Function
GO:0005496 steroid binding
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0050661 NADP binding
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0102196 cortisol dehydrogenase activity
Biological Process
GO:0006706 steroid catabolic process
GO:0008202 steroid metabolic process
GO:0030324 lung development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:6nj7, PDBe:6nj7, PDBj:6nj7
PDBsum6nj7
PubMed31294974
UniProtP28845|DHI1_HUMAN 11-beta-hydroxysteroid dehydrogenase 1 (Gene Name=HSD11B1)

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