Structure of PDB 6nfj Chain D

Receptor sequence
>6nfjD (length=846) Species: 9606 (Homo sapiens) [Search protein sequence]
FSGDGRAIWSDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHV
SSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKG
LQYYSTLLDALVLRNIEPIVTLYHWDLPLALQEKYGGWKNDTIIDIFNDY
ATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGH
NLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQRSENTMDIFKCQQ
SMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFA
FSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFT
DSRVKTEDTTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDA
YTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGTPDVQGQFPCDFSW
GVTESVLKPCTDFVNIKKQLEMLARMKVTHYRFALDWASVLPTGQLSAVN
RQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPST
AEAFQAYAGLCFQELGDLVKLWITINEPNRLSDNDTYGAAHNLLVAHALA
WRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWF
AEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCA
LNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKL
LRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDK
VRIKGYYAFKLAEEKSKPRFGFFTSDFKAKSSIQFYNKVISSRGFP
3D structure
PDB6nfj Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
ChainD
Resolution3.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D W419 M435 F826 F849 L850 Q851 F931 F942 W348 M364 F704 F727 L728 Q729 F809 F820
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:6nfj, PDBe:6nfj, PDBj:6nfj
PDBsum6nfj
PubMed30944224
UniProtQ86Z14|KLOTB_HUMAN Beta-klotho (Gene Name=KLB)

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