Structure of PDB 6ne5 Chain D

Receptor sequence
>6ne5D (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMSGATSRKALETLRRVGDGVQRN
HETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAF
VAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB6ne5 Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
ChainD
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KJP D H224 A227 F228 V249 M250 V253 F254 V258 N260 R263 T266 L267 F270 G271 I294 H51 A54 F55 V76 M77 V80 F81 V85 N87 R90 T93 L94 F97 G98 I121 MOAD: Ki=0.058nM
BindingDB: Ki=0.058000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6ne5, PDBe:6ne5, PDBj:6ne5
PDBsum6ne5
PubMed30929420
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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