Structure of PDB 6ncz Chain D

Receptor sequence
>6nczD (length=589) Species: 1150298 (Fusicatenibacter saccharivorans) [Search protein sequence]
MSDIHLEDYTEQYETGFATVDTMIFEGGRREELLNGGWHYAVDQYDTCLR
QKWYKERYRDEKGFTVPIDYSFDEWPVMQLPCSWNTIDPMYLLYEGSMVF
TRKFSYIAEREETVFLKVGAANYLCRVFLNGKYVGMHRGGSTPAFWNITE
YLKAENRIVLAVDGTRRPEQVPTENTDWFNYCGVYRDIALIRVPKCHIKT
FKIALVPDGTFGHVMAKVTLSEKITAKAELVIEELGVSRKIQLENGAGEV
VFDAKPELWTPEKPKLYDVKVTCGTDTVSDRVGFREIRVNGRDILLNGEP
VFLRGISCHEDSVENGKGLTREERIENIRIAKELGCNFMRLAHYPHNEEM
AKLADELGLLLWEEIPVYWAIRFEREKTYEDAQNQLRELINRDWNRASVI
IWSVGNENADTDERLKFMSVLAECAHREDETRMVSAACLVNAAKNKIEDR
LMEYLDIIGINEYCGWYTPDFAMLPALMENSQPDKPVIVTEFGADALPHH
HGTISDKGTEECQADVYEKQIATLRNIDYIKGMTPWILYDFRCPRRTSLI
QKYYNRKGLLSEDKKYRKPAFYVLQKFYEELKRKEQENL
3D structure
PDB6ncz Selecting a Single Stereocenter: The Molecular Nuances That Differentiate beta-Hexuronidases in the Human Gut Microbiome.
ChainD
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.31: beta-glucuronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FYJ D D177 H343 Y368 N406 E407 N461 Y463 Y467 E491 W536 R546 N555 K557 D177 H343 Y368 N406 E407 N461 Y463 Y467 E491 W536 R546 N555 K557
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0004566 beta-glucuronidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6ncz, PDBe:6ncz, PDBj:6ncz
PDBsum6ncz
PubMed30729778
UniProtA0A174EHD1

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