Structure of PDB 6mse Chain D

Receptor sequence
>6mseD (length=380) Species: 9606 (Homo sapiens) [Search protein sequence]
DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLV
IGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNA
LVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHF
ELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQK
YLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRI
LLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDR
RQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVR
ENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
3D structure
PDB6mse Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
ChainD
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D H135 K238 E284 H97 K200 E246
BS02 ATP D P208 G209 G211 K212 T213 M214 G372 N376 P170 G171 G173 K174 T175 M176 G334 N338
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mse, PDBe:6mse, PDBj:6mse
PDBsum6mse
PubMed30479383
UniProtP43686|PRS6B_HUMAN 26S proteasome regulatory subunit 6B (Gene Name=PSMC4)

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