Structure of PDB 6mm1 Chain D

Receptor sequence
>6mm1D (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]
SGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELSGCNAAILKRE
TMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAH
RFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGD
3D structure
PDB6mm1 The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a).
ChainD
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C426 C428 H491 H535 C9 C11 H74 H118
BS02 ZN D C494 C497 H520 C523 C77 C80 H103 C106
BS03 ZN D C446 C459 C481 H484 C29 C42 C64 H67
BS04 ZN D C509 H517 C533 C536 C92 H100 C116 C119
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6mm1, PDBe:6mm1, PDBj:6mm1
PDBsum6mm1
PubMed34278292
UniProtQ96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)

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