Structure of PDB 6mhm Chain D

Receptor sequence
>6mhmD (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
CTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQ
RNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILG
KKDAMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGC
VITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLN
RTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPC
IGW
3D structure
PDB6mhm Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur.
ChainD
Resolution2.743 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.109: sphingomyelin deacylase.
3.5.1.23: ceramidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JRY D C143 M161 F163 E225 N320 C1 M19 F21 E83 N178
External links
PDB RCSB:6mhm, PDBe:6mhm, PDBj:6mhm
PDBsum6mhm
PubMed30525581
UniProtQ13510|ASAH1_HUMAN Acid ceramidase (Gene Name=ASAH1)

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