Structure of PDB 6m6c Chain D

Receptor sequence
>6m6cD (length=1305) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGP
IKDYECACGKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHI
WFVKDVPSKIGTLLDLSATELEQVLYFSKYIVLDPKGAILNGVPVEKRQL
LTDEEYRELRYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV
ALYRFPREPASILVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDV
YGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEM
KHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVD
GGRFATSDLNDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDAL
LDNGRRGAPVTNPGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVI
VVGPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQR
DIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQSIQLHPL
VCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAKP
SRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAG
RETSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRIL
FARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGMEKTARLL
DALKYYGFTFSTTSGITIGIDDAVIPEEKKQYLEEADRKLLQIEQAYEMG
FLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGN
PQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGG
ADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRS
LRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAG
EIQEVPVRSPLTCQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGE
PGTQLTQGLPRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESE
GFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERY
LVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQVLEK
WDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVL
TEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEE
ARKEA
3D structure
PDB6m6c Structural basis of Mfd-dependent transcription termination.
ChainD
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D Y34 R1266 Y32 R1069
BS02 dna D S485 R534 R586 K610 R628 A705 Y1093 Q1441 N1442 S304 R353 R405 K429 R447 A524 Y912 Q1244 N1245
BS03 ZN D C1112 C1194 C1201 C1204 C931 C1013 C1020 C1023
BS04 ZN D C58 C60 C73 C56 C58 C71
BS05 MG D D739 D741 D743 D558 D560 D562
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m6c, PDBe:6m6c, PDBj:6m6c
PDBsum6m6c
PubMed33068413
UniProtQ8RQE8|RPOC_THET8 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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