Structure of PDB 6lz1 Chain D

Receptor sequence
>6lz1D (length=1076) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
TLFPVLNNTPVGKQVDSIYESRLDQFLSEGQYRDFNLPSVYDHARIDNPS
GDVNNDLSKGFVDLKVYRVPDLSRPSFNEVVGHKKFDETASKGDTFGPSW
ATFWFEVHIRLPKSWAKYEQVIFQWNCDNEGLVYSQDGVPLQAFSGSERT
DFILPDSWKTTEDTFYIEMACNGMFGTGAGSQIAPPDPNRYFTLTKADLV
APNLPAMALAYDFLLMQQCVKQLPSNCWQKYKARQICNDIMNTFHPNDLS
TINECRNLAKAFLGNDIDSEAVFEKNNDKANVFAIGHCHIDTAWLWPFAE
TRRKIVRSWATQMNIMDRYPEYQFVCSQALQYLWLKEDHPDVFEKLKEYV
NQNKFIPIGGSWVEHDTNIPNGESLIRQFLLGQHFFEKEFGVRCRTFWLP
DTFGYSSQIPQICRLCGMDRFLTQKLSWNNINSFPTSTFNWVALDGSQVI
CHMPPANTYTADTNVNDVLHSIDQHKNLVNDQAGLLVFGIGDGGGGPTPE
MLEKLRRCKGIANTVGYLPNVKLGNTVDEFFDGILKRTNAGQTLPSWNGE
LYFEFHRGTYTTQAELKKLMRKVEIALHDAEYVSTLASIFSKDYSYPKES
LQDLWRDTLLCQFHDVLPGSCIEMVYKDAIPIMSKVLKNTEALLWQAIEQ
LGFKKASSSDNKEQLCLLNTLPWNVRGVITETEENKLVYFESCDGKGILT
AAHTSLKHPAAAYQKDDNFILVNDHLRVTIAPNGLILSLFDLHKEREILD
LKSGKNHAGANQYVLFEDTPLSWQAWDTEVFSLEKYEVLDKGKVSIKESG
PLRASVVVDIPISELSHMKATISLEGYNDCSEFTGVNFTCEVDWHESCKF
LKVEFPVDIHSEFASYETQFGITKRPTHYNTSWDVAKFEVCHQKFADYSD
FTYGVSVLNDCKYGFSTHGNLMRLSLLRSPKQPDAHADMGKHTIRYAVYP
HSKPLDSSTVRAAHKFNSNFRLLTRASDTANLDIFDAFQLVGEPNVILSH
IKMAEKGKSIILRVYESLGGKSRARLVIKSLTVASVTKCNGLEEDLEELC
TLKSNDYYEVPIELRAFEIATFKVNL
3D structure
PDB6lz1 Cryo-EM structure of fission yeast tetrameric alpha-mannosidase Ams1.
ChainD
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.24: alpha-mannosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D D292 D402 D291 D401
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004559 alpha-mannosidase activity
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005515 protein binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity
GO:0052768 mannosyl-oligosaccharide 1,3-alpha-mannosidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006013 mannose metabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0000328 fungal-type vacuole lumen
GO:0000329 fungal-type vacuole membrane
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lz1, PDBe:6lz1, PDBj:6lz1
PDBsum6lz1
PubMed32981237
UniProtQ9UT61|MAN1_SCHPO Alpha-mannosidase (Gene Name=ams1)

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