Structure of PDB 6lwj Chain D

Receptor sequence
>6lwjD (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
GQGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QPDLLELCHSVPKEVVQLGGKGYGEEDFAAFRAWLRCYGMPGMSSLQDRH
GRTIWFQGDPGPLAP
3D structure
PDB6lwj DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainD
Resolution2.83 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D G2 Q3 E6 K54 R78 M81 R118 F120 R133 Q168 N176 K242 Y263 R277 G1 Q2 E5 K53 R77 M80 R117 F119 R132 Q167 N175 K221 Y238 R252
BS02 dna D R34 R95 H96 I117 R118 R119 F120 R33 R94 H95 I116 R117 R118 F119
BS03 dna D K155 R159 K154 R158
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6lwj, PDBe:6lwj, PDBj:6lwj
PDBsum6lwj
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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