Structure of PDB 6lu8 Chain D

Receptor sequence

>6lu8D (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]

RPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAV
SELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAP
TKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVV
EDKVEGYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQR
RGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTE
SAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRA
PRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKA
AAAAAAL

3D structure

PDB

6lu8 Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

Chain

Resolution

3.13 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	R33 N38 F39 T42 N43 R45 K46 N47 N48 R49 Q50 Y52 V54 S55 E56 A58 H60 S63 T69 G70 R71 A72 V73 A74 R75 P77 R80 G83 T84 R86 Q89 N94 M95 R97 R100 M101 F102 A103 K106 W108 R109 R110 R114 N116 T117 T118 Q119 R121 Y122 K140 R143 K163 T164 K165 K172 N178 K181 K182 Y184 R188 R190 A191 G192 R197 R199 R204 R205 K219 R222 N223 N236 K239 P242 G243 H245 R268 K274 S275 R291 L293 R303 A304 P305 R306 K307 K308 H310 R311 R312 K316 K320 N321 L322 R323 I324 L326 K333 R336 T339 R342 Q343 N346 R350	R29 N34 F35 T38 N39 R41 K42 N43 N44 R45 Q46 Y48 V50 S51 E52 A54 H56 S59 T65 G66 R67 A68 V69 A70 R71 P73 R76 G79 T80 R82 Q85 N90 M91 R93 R96 M97 F98 A99 K102 W104 R105 R106 R110 N112 T113 T114 Q115 R117 Y118 K136 R139 K159 T160 K161 K168 N174 K177 K178 Y180 R184 R186 A187 G188 R193 R195 R200 R201 K215 R218 N219 N232 K235 P238 G239 H241 R264 K270 S271 R287 L289 R299 A300 P301 R302 K303 K304 H306 R307 R308 K312 K316 N317 L318 R319 I320 L322 K329 R332 T335 R338 Q339 N342 R346
BS02	rna	D	P51 A53 S55 T107 K195 M196	P47 A49 S51 T103 K191 M192

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6lu8, PDBe:6lu8, PDBj:6lu8
PDBsum	6lu8
PubMed	32669547
UniProt	P36578\|RL4_HUMAN Large ribosomal subunit protein uL4 (Gene Name=RPL4)

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