Structure of PDB 6ldi Chain D

Receptor sequence
>6ldiD (length=1331) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
FDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCARIFGPVK
DYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWF
LKSLPSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYL
DALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKK
LTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLDGGRFATSDLN
DLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQEAVDALLDNGRRGRAI
TGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPYLRLHQC
GLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVI
REHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQM
AVHVPLTLEAQLEARALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRD
CVNAKGEGMVLTGPKEAERLYRSGLASLHARVKVRITEYEKDANGELVAK
TSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKP
TVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAEVAEIQE
QFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQ
VSFNSIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREG
LNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGT
HEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADILVPRNTLLHE
QWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYGRDLARGHIINKGEAIG
VIAAQSIGEPGTQLTSSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNTEL
KLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTMPVITEVS
GFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKIVD
AQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQGLPRVA
DLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPK
WRQLNVFEGERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYR
LQGVKINDKHIEVIVRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANREL
EANGKVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAAVAGKRD
ELRGLKENVIVGRLIPAGTGYAYHQDRMRRR
3D structure
PDB6ldi CueR activates transcription through a DNA distortion mechanism.
ChainD
Resolution3.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D Y46 R47 R1148 Y30 R31 R1106
BS02 dna D N320 K334 R346 A426 Y795 Q1326 E1327 N304 K318 R330 A410 Y779 Q1284 E1285
BS03 ZN D C70 C85 C54 C69
BS04 ZN D C895 C898 C879 C882
BS05 MG D D460 D462 D464 D444 D446 D448
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006879 intracellular iron ion homeostasis
GO:0009408 response to heat
GO:0031564 transcription antitermination
GO:0032784 regulation of DNA-templated transcription elongation
GO:0036460 cellular response to cell envelope stress
GO:0042128 nitrate assimilation
GO:0044780 bacterial-type flagellum assembly
GO:0046677 response to antibiotic
GO:0048870 cell motility
GO:0071973 bacterial-type flagellum-dependent cell motility
GO:0090605 submerged biofilm formation
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008023 transcription elongation factor complex
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ldi, PDBe:6ldi, PDBj:6ldi
PDBsum6ldi
PubMed32989300
UniProtP0A8T7|RPOC_ECOLI DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

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