Structure of PDB 6l2c Chain D

Receptor sequence
>6l2cD (length=398) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
EIQEAYILSGARTPTAKFNGSFVSVSAPELGAVAIKSAVSKSGVPVEKIT
DVYMGNVLQGAVGQAPARQASMFAGLSPTVESMTVNKVCASGLKAVALAA
QNIQLGLAEAQVAGGMENMSRVPYYLPRSTQLPPFGEIKLQDGLIQDGLW
DVYNQFHMGICAEKTAKKYEISREEQDQYAIQSYQRAQAAWKENKFAEEI
APVTVKGKKGETVVERDEGYENLRIDKMATLKPAFLRDGTGTVTAGNAST
MNDGASALVLGSKAIAREFAQGNRALARIVSTADAAIDPVDFPVAPAKAV
PIALERAGITKDQVAVWEFNEAFAAVIKANEKILGLQNARVNPLGGAISL
GHALGSSGSRILVTLLHQLQPGEYGVAAICNGGGAATAMVVQKLDRVD
3D structure
PDB6l2c Aspergillus fumigatus Mitochondrial Acetyl Coenzyme A Acetyltransferase as an Antifungal Target.
ChainD
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C124 H387 C415 G417
Catalytic site (residue number reindexed from 1) C89 H352 C380 G382
Enzyme Commision number 2.3.1.9: acetyl-CoA C-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA D C124 Y219 R259 L266 S284 F358 C89 Y184 R224 L231 S249 F323
Gene Ontology
Molecular Function
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6l2c, PDBe:6l2c, PDBj:6l2c
PDBsum6l2c
PubMed32005728
UniProtB0XMC1|ER10A_ASPFC Acetyl-CoA acetyltransferase erg10A, mitochondrial (Gene Name=erg10A)

[Back to BioLiP]