Structure of PDB 6kpp Chain D

Receptor sequence
>6kppD (length=418) Species: 9823 (Sus scrofa) [Search protein sequence]
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNENKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAK
GHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLIS
KIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCID
NEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKL
AVNMVPFPRLHFFMPGFAPLLTVPELTQQMFDSKNMMAACDPRHGRYLTV
AAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKM
SATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAES
NMNDLVSEYQQYQDATAD
3D structure
PDB6kpp Unraveling the molecular mechanism of BNC105, a phase II clinical trial vascular disrupting agent, provides insights into drug design.
ChainD
Resolution2.74524 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DO6 D V236 C239 L246 A248 K252 L253 N256 M257 N348 K350 V233 C236 L243 A245 K249 L250 N253 M254 N335 K337
BS02 MG D Q11 N99 Q11 N96
BS03 GDP D G10 Q11 C12 I16 S138 G141 G142 T143 D177 E181 N204 Y222 N226 G10 Q11 C12 I16 S135 G138 G139 T140 D174 E178 N201 Y219 N223
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kpp, PDBe:6kpp, PDBj:6kpp
PDBsum6kpp
PubMed32085900
UniProtP02554|TBB_PIG Tubulin beta chain

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