Structure of PDB 6kdl Chain D

Receptor sequence
>6kdlD (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
RRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEG
NIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGR
LFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKK
VQTITTKSNSQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGAR
QKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB6kdl Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B.
ChainD
Resolution3.274 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH D F581 G583 T586 E605 V606 C607 D627 V628 L671 R832 S833 W834 F11 G13 T16 E35 V36 C37 D57 V58 L101 R256 S257 W258 BindingDB: IC50=300nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6kdl, PDBe:6kdl, PDBj:6kdl
PDBsum6kdl
PubMed32083663
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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