Structure of PDB 6jg3 Chain D

Receptor sequence

>6jg3D (length=3477) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD
LSICTFVLEQSLSVRALQEMLANTFMMKTAQGGGHRTLLYGHAILLRHSY
SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKV
RVGDDLILVSVSSERYLHLSYLHVDAAFQQTLWSVAPISSGSEAAQGYLI
GGDVLRLLHGECLTVPSGEHEQRRTVHYEGGAVSVHARSLWRLETLRVAW
SGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSS
KEKRKEVDGMGTSEIKYGDSVCFIQHIGTGLWLTYQSSIQRKAIMHHEGH
MDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLP
IESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLV
LECIDRLHVYSSVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGS
LDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKH
GRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSS
MRPNIFLGKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEE
WGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLS
APSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGEFKFLPP
PGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSAFTPIPVDTS
QIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVE
FSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAYQLTSGYKPAPMD
LSFIKLTPSQEAMVDKLAENAHNVWARDRIRQRRNPRLVPYALLDDRTKK
SNKDSLREAVRTLLGYGYNLEARFRIFRAEKTYAVKAGRWYFEFEAVTAG
DMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDV
VGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQ
VGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV
PSSHEHIEVTRIDVTQKSFGSQNSSTDIMFYRLSMPIECTYYYSVRIFPN
VWVGWITSDFHQYDTAFDLVTVTLGDEKGKVHESIKRSNYMVCANNNGLE
IGCVVGLLTFTANGKDLSTYYQVEPSTKLFPAVFAQATSPNVFQFEAGLF
KSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQC
LEPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHR
VAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMM
NNEFIVPMTEETKSITLFPDGLPGIGLSTSLRPRMQFSSPSNECYQYSPE
FPLDILKAKTIQMLTEAVQEGSLHARDPVGGTTEFLFVPLIKLFYTLLIM
GIFHNEDLKHILQLIEPSGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIE
AIVAFSDDFVAKLQDNQRFRYNEVRDQLLDFHEDLMTHCGIELDSDLTIR
GRLLSLVEKVTYLTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYD
GIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMI
RGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGFPKMVANCCRFLC
YFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNN
ELALALREPDLEKVVRYLAGCGLPVEGERYLDFLRFAVFCNGESVEENAN
VVVRLLIRRPEGLLAAMEEAIKIGNAIMTFYAALIDLLGRCAEAIRIRSI
LRSGDLVGVISIAFQFCPDHKAAMVLFLDRVYVQDFLLHLLGFLPDLRAA
ASLTDMALALNRYLCTAVLPLLLFAGTEHHASLIDSLLHTVKGCSLTKAQ
RDSIEVCLLSRPSMMQHLLRRLVFDVPLLNKMPLKLLTNHYERCWKYYCL
PGGASEEELHLSRKLFWGIFDALYEQELFKLALPCLSAVAGALPPNFNPQ
PVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQ
PLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDVDAAHGYS
PRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLV
PYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGYFLSAASRPLCSGGHA
SNKEKEMVFCKLGVLVRHRISLFGNDATLHILGQTLDARTVMKTGLESVK
FLDNAAEDLEKTMENLKQGQFTTTVALLPMLSSLFEHIGQHQFLEDVQVS
CYRILTSLYALGTSVERQRSALGECLAAFAGAAFLETHLDKHNIYSPRHR
AVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPRVDPLHQLILLFSRTALT
EKCKLEEDFLYMAYADIMAKSCSFEEKEMEKQKLLYQQARLHDRGAAEMV
LQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLEYLKEKKDVGFF
QSLAGLMQSCSVLDLNAFERQNKAEGKVLQDDEFTCDLFRFLQLLCEGHN
SDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQ
GQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVF
AHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVD
MLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKA
MESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVL
LTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFE
ISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQ
LAAQIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVVHYVLEE
SSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFD
GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGR
DRISELLGSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNN
FFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAF
NFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAG
DEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMET
KCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQ
ESYVWKMYQERCWEFFPAGDCFRKQYE

3D structure

• PDB: 6jg3 Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
• Chain: D
• Resolution: 6.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	D	C4892 H4914 G4956	C3405 H3427 G3469

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Dec 1 18:00:05 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6jg3', asym_id = 'D', title = 'Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6jg3', asym_id='D', title='Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6jg3', asym_id = 'D'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6jg3', asym_id='D')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>