Structure of PDB 6j61 Chain D

Receptor sequence
>6j61D (length=242) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
LTIPVLDKGFVRLVDQMGDDRAIVQAARVSYGEGTKTVREDAALIDYLMR
HRHTSPFEMVVFKFHVKAPIFVARQWFRHRTASVNEISGRYSILKEEFYE
PEAFRKQLLRKVQQEAYGAYRALLEKGVAREMARMVLPLNLYTEFYWKQD
LHNLFHFLKLRLAPEAQWEIRQYARAIAEIVKERVPLAWAAFEEHLLEGA
FLSRTELRALRGLLTPEVYEKALSSLGLGGSRLKEALEKVFG
3D structure
PDB6j61 Crystal structure of the flavin-dependent thymidylate synthase Thy1 from Thermus thermophilus with an extra C-terminal domain.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD D H83 R84 T85 H179 H79 R80 T81 H156
BS02 PO4 D Q79 R82 Q75 R78
BS03 FAD D T85 A86 N89 E90 T81 A82 N85 E86
BS04 FAD D H57 S59 H175 N176 H53 S55 H152 N153
BS05 PO4 D S92 G93 R94 R157 S88 G89 R90 R134
BS06 PO4 D Q79 R82 R184 Q75 R78 R161
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6j61, PDBe:6j61, PDBj:6j61
PDBsum6j61
PubMed31204692
UniProtQ5SJB8|THYX_THET8 Flavin-dependent thymidylate synthase (Gene Name=thyX)

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