Structure of PDB 6iwr Chain D

Receptor sequence
>6iwrD (length=538) Species: 9606 (Homo sapiens) [Search protein sequence]
YLTFKPQTFTYHDPVLRPGILGNFEPKEPEPPGVVGGPGEKAKPLVLGPE
FKQAIQASIKEFGFNMVASDMISLDRSVNDLRQEECKYWHYDENLLTSSV
VIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLDEY
IKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWY
APLVAPISKDRTICTVPLIDVINGNTYEIIPQGGGDEDGYARGAWDWSML
WKRVPLTPQEKRLRKTKTEPYRSPAMAGGLFAIEREFFFELGLYDPGLQI
WGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGSSPTLKNYVRVV
EVWWDEYKDYFYASRPESQALPYGDISELKKFREDHNCKSFKWFMEEIAY
DITSHYPLPPKNVDWGEIRGFETAYCIDSMGKTNGGFVELGPCHRMGGNQ
LFRINEANQLMQYDQCLTKGADGSKVMITHCNLNEFKEWQYFKNLHRFTH
IPSGKCLDRSEVLHQVFISNCDSSKTTQKWEMNNIHSV
3D structure
PDB6iwr Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7.
ChainD
Resolution2.604 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP D V214 F215 D247 R277 L280 D301 A302 H303 V103 F104 D136 R166 L169 D190 A191 H192
BS02 MN D D301 H303 H440 D190 H192 H329
BS03 UD2 D D547 M549 H563 M565 G567 N568 D428 M430 H444 M446 G448 N449
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6iwr, PDBe:6iwr, PDBj:6iwr
PDBsum6iwr
PubMed30685086
UniProtQ86SF2|GALT7_HUMAN N-acetylgalactosaminyltransferase 7 (Gene Name=GALNT7)

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