Structure of PDB 6iid Chain D

Receptor sequence
>6iidD (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
AEKAVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGD
ADRKHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAE
TFYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRG
DGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAI
GFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQE
FTLYLSTRKVLRLEKIMENLKNAEIEPDDYFMSRYEKK
3D structure
PDB6iid A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication.
ChainD
Resolution2.986 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C56 A84 N106 N115 E123
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna D R109 K110 S137 R138 G139 A144 G145 K148 F168 N171 S172 N176 R183 Y310 L311 R314 R53 K54 S81 R82 G83 A88 G89 K92 F112 N115 S116 N120 R127 Y254 L255 R258 PDBbind-CN: Kd=1.03uM
BS02 dna D S172 L311 K315 S116 L255 K259 PDBbind-CN: Kd=1.03uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6iid, PDBe:6iid, PDBj:6iid
PDBsum6iid
PubMed30949702
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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