Structure of PDB 6igs Chain D

Receptor sequence
>6igsD (length=158) Species: 263 (Francisella tularensis) [Search protein sequence]
TYSAENTEVYITSQQLEQAVTRLAEQINQDYSGQQVTLVCVLKGSFMFFA
DLVRKLRIDLRTQFITASSKEEYVKDKNIIIIEDIVDTGHTYHKLIEGIG
KYNPKTLKFATLLFKPARLERDVKLDYVCFEIEDKFIVGYGLDFDEKYRE
LPYIGLIK
3D structure
PDB6igs Crystal structure of hypoxanthine phosphoribosyltransferase from Francisella tularensis
ChainD
Resolution2.16 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E102 D103 D106 F155 R168
Catalytic site (residue number reindexed from 1) E83 D84 D87 F136 R149
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D E102 D103 E83 D84
BS02 ZN D H109 H112 E139 H90 H93 E120
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:6igs, PDBe:6igs, PDBj:6igs
PDBsum6igs
PubMed
UniProtQ5NI77

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