Structure of PDB 6hth Chain D

Receptor sequence
>6hthD (length=384) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDS
PSRMYEAVTAFHSTEYVDALKKLQMLHCEELTADDELLMDSFSLNYDCPG
FPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGFCY
LNDIVLAIHRLVSSTRVLYVDLDLHHGDGVEEAFWYSPRVVTFSVHHASP
GFFPGTGTWNLPIFLNGAGRGRFSAFNLPLEEGINDLDWSNAIGPILDSL
NIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLYAIKKILSWKV
PTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTISPEIPEHSYFSRY
GPDFELDIDYFPSIQKHHRRILEQLRNYADLNKL
3D structure
PDB6hth Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
ChainD
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GQN D D50 R54 D49 R53 MOAD: ic50=75nM
BindingDB: IC50=76nM
BS02 ZN D D186 H188 D285 D173 H175 D266
BS03 GQN D K20 D100 H141 H142 G150 D186 H188 F216 P291 H292 Y341 K19 D97 H138 H139 G147 D173 H175 F203 P272 H273 Y310 MOAD: ic50=75nM
BindingDB: IC50=76nM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hth, PDBe:6hth, PDBj:6hth
PDBsum6hth
PubMed30347148
UniProtA5H660

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