Structure of PDB 6hdu Chain D

Receptor sequence
>6hduD (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMQAPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFAL
KVLHWDPETVVRLQLWDIAGLERFGNMTRVYYREAMGAFIVFDVTRPATF
EAVAKWKNDLDSKLSLPNGKPVSVVLLANKCDQKMDQFCKEHGFVGWFET
SAKENINIDEASRCLVKHILANE
3D structure
PDB6hdu LRRK2 binds to the Rab32 subfamily in a GTP-dependent mannerviaits armadillo domain.
ChainD
Resolution1.793 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP D L18 G19 G21 K22 T23 S24 S36 Y38 T41 G68 N127 K128 D130 S159 K161 L20 G21 G23 K24 T25 S26 S38 Y40 T43 G70 N129 K130 D132 S151 K153 MOAD: Kd=1.2uM
BS02 MG D T23 T41 T25 T43
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0031982 vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hdu, PDBe:6hdu, PDBj:6hdu
PDBsum6hdu
PubMed31552791
UniProtP57729|RAB38_HUMAN Ras-related protein Rab-38 (Gene Name=RAB38)

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