Structure of PDB 6hc3 Chain D

Receptor sequence

>6hc3D (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]

SSVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELP
DSKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKA
MTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNL
SDSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRT

3D structure

PDB

6hc3 DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	K51 K52 V54 L58 K62 T77 I81 H137 M143 K147 R157 Y162 Q179 L182 K186 K190 Y211 R232 R233 T234	K9 K10 V12 L16 K20 T35 I39 H95 M101 K105 R115 Y120 Q137 L140 K144 K148 Y169 R190 R191 T192	PDBbind-CN: Kd=13.6nM
BS02	dna	D	S55 Y57 L58 S61 T78 I81 A85 W88 R89 Q100 Y103 W107 R140 K147 K156 R157 N163 F170 P178 L182	S13 Y15 L16 S19 T36 I39 A43 W46 R47 Q58 Y61 W65 R98 K105 K114 R115 N121 F128 P136 L140	PDBbind-CN: Kd=13.6nM

External links

PDB	RCSB:6hc3, PDBe:6hc3, PDBj:6hc3
PDBsum	6hc3
PubMed	31114891
UniProt	Q00059\|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)

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