Structure of PDB 6hb4 Chain D

Receptor sequence

>6hb4D (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]

SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPD
SKKKIYQDAYRAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAM
TKKKELTLLGKPKRPRSAYNVYVAERFQEAKGDSPQEKLKTVKENWKNLS
DSEKELYIQHAKEDETRYHNEMKSWEEQMIEVGRKDLLRRTIKK

3D structure

PDB

6hb4 DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region.

Chain

Resolution

3.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	K52 Y103 W107	K9 Y60 W64	PDBbind-CN: Kd=4.4nM
BS02	dna	D	V54 L58 K62 T77 K139 R140 M143 K146 K147 R157 Y162 Q179 L182 K186 W189 Y211 R232 R233	V11 L15 K19 T34 K96 R97 M100 K103 K104 R114 Y119 Q136 L139 K143 W146 Y168 R189 R190	PDBbind-CN: Kd=4.4nM
BS03	dna	D	Y57 T78 I81 R82 A85 W88 R89 R140 K156 R157 R159 N163 V166 A167 F170 P178	Y14 T35 I38 R39 A42 W45 R46 R97 K113 R114 R116 N120 V123 A124 F127 P135	PDBbind-CN: Kd=4.4nM

External links

PDB	RCSB:6hb4, PDBe:6hb4, PDBj:6hb4
PDBsum	6hb4
PubMed	31114891
UniProt	Q00059\|TFAM_HUMAN Transcription factor A, mitochondrial (Gene Name=TFAM)

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