Structure of PDB 6h3m Chain D
Receptor sequence
>6h3mD (length=30) Species:
9606
(Homo sapiens) [
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FVNQHLCGSHLVEALYLVCGERGFFYTPKT
3D structure
PDB
6h3m
Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin.
Chain
D
Resolution
1.821 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
?
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
peptide
D
V2 Q4
V2 Q4
BS02
peptide
D
S9 H10 V12 E13 Y16 F24 F25 Y26
S9 H10 V12 E13 Y16 F24 F25 Y26
BS03
peptide
D
F1 H5 L6 C7 L15 V18 C19 R22 G23 F24 F25 P28 K29
F1 H5 L6 C7 L15 V18 C19 R22 G23 F24 F25 P28 K29
BS04
peptide
D
N3 L17 V18
N3 L17 V18
BS05
peptide
D
Y16 G20 E21
Y16 G20 E21
Gene Ontology
Molecular Function
GO:0005179
hormone activity
Cellular Component
GO:0005576
extracellular region
View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB
RCSB:6h3m
,
PDBe:6h3m
,
PDBj:6h3m
PDBsum
6h3m
PubMed
31012517
UniProt
P01308
|INS_HUMAN Insulin (Gene Name=INS)
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