Structure of PDB 6gyr Chain D

Receptor sequence

>6gyrD (length=584) Species: 9606 (Homo sapiens)

AKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVK
SPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSK
LSEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSY
QNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELF
VECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLP
STRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFV
DSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVY
ISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGD
DYIFHCHPPDQKIPKPKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDR
LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTKPGMPNVSNDL
SQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPDPLIPCDLMDGRDAF
LTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD

3D structure

• PDB: 6gyr Transcription factor dimerization activates the p300 acetyltransferase.
• Chain: D
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	D	H1255 C1258	H211 C214
BS02	ZN	D	C1247 C1250 C1272	C203 C206 C228
BS03	ZN	D	C1183 C1204	C139 C160
BS04	01K	D	S1396 Y1397 L1398 D1399 S1400 R1410 T1411 Y1414 W1436 C1438 P1440 Y1446 K1456 I1457 P1458 R1462 L1463 W1466 F1467	S352 Y353 L354 D355 S356 R366 T367 Y370 W392 C394 P396 Y402 K412 I413 P414 R418 L419 W422 F423

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:6gyr, PDBe:6gyr, PDBj:6gyr
• PDBsum: 6gyr
• PubMed: 30323286
• UniProt: Q09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)